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Scientific Publications

deepCDR Biologic's proprietary mammalian display platform:
Pogson, M. et al. (2016) Immunogenomic engineering of a plug-and-(dis)play hybridoma platform. Nat. Commun. 7:12535,

Antibody engineering in our mammalian display platform:
Derek M Mason, Cédric R Weber, Cristina Parola, Simon M Meng, Victor Greiff, William J Kelton, Sai T Reddy, High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis, Nucleic Acids Research, Volume 46, Issue 14, 21 August 2018, Pages 7436–7449,

Expanding antibody optimization within our mammalian cell platform with deep learning:
Mason,D.M., Friedensohn,S., Weber,C.R., Jordi,C., Wagner,B., Meng,S.M., Ehling,R.A., Bonati,L., Dahinden J., Gainza,P., Correia,B.E. and Reddy,S.T. (2021) Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning. Nature Biomedical Engineering,

De novo antibody discovery using our mammalian display platform:
Parola, C., Neumeier, D., Friedensohn, S., Csepregi, L., Di Tacchio, M., Mason, D. M., & Reddy, S. T. (2019, November). Antibody discovery and engineering by enhanced CRISPR-Cas9 integration of variable gene cassette libraries in mammalian cells. In mAbs (Vol. 11, No. 8, pp. 1367-1380). Taylor & Francis.

Computational Discovery Workflow
Friedensohn, S., Neumeier, D., Khan, T. A., Csepregi, L., Parola, C., de Vries, A. R. G., ... & Reddy, S. T. (2020). Convergent selection in antibody repertoires is revealed by deep learning. bioRxiv

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